2024
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.

Nature genetics 56, 889-899 (2024)
Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

bioRxiv : the preprint server for biology (2024)
Disentangling oncogenic amplicons in esophageal adenocarcinoma.

Nature communications 15, 4074 (2024)
2023
ESQmodel: biologically informed evaluation of 2-D cell segmentation quality in multiplexed tissue images.

Bioinformatics (Oxford, England) 40, (2023)
Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs.

PloS one 18, e0291506 (2023)
A MYCN-independent mechanism mediating secretome reprogramming and metastasis in MYCN-amplified neuroblastoma.

Science advances 9, eadg6693 (2023)
Identification of transcriptional programs using dense vector representations defined by mutual information with GeneVector.

Nature communications 14, 4400 (2023)
Obesity-associated changes in molecular biology of primary breast cancer.

Nature communications 14, 4418 (2023)
Multi-Omic Analysis of CIC's Functional Networks Reveals Novel Interaction Partners and a Potential Role in Mitotic Fidelity.

Cancers 15, (2023)
Single-cell DNA replication dynamics in genomically unstable cancers.

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Nature communications 14, 982 (2023)
2022
Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies.

eLife 11, (2022)
Single-cell genomic variation induced by mutational processes in cancer.

Nature 612, 106-115 (2022)
Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.

Nature communications 13, 4534 (2022)
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

Nature communications 13, 3607 (2022)
Breast tumor microenvironment structures are associated with genomic features and clinical outcome.

Nature genetics 54, 660-669 (2022)
Three-dimensional imaging mass cytometry for highly multiplexed molecular and cellular mapping of tissues and the tumor microenvironment.

Nature cancer 3, 122-133 (2022)
2021
Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence.

BMC genomics 22, 869 (2021)
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Nature communications 12, 5406 (2021)
Clonal fitness inferred from time-series modelling of single-cell cancer genomes.

Nature 595, 585-590 (2021)
A Scalable Strand-Specific Protocol Enabling Full-Length Total RNA Sequencing From Single Cells.

Front Genet 12, 665888 (2021)
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461.

Sci Rep 11, 9812 (2021)
Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response.

Nature communications 12, 1998 (2021)
Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes.

Cell 184, 2239-2254.e39 (2021)
2020
Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data.

PLoS Comput Biol 16, e1008270 (2020)
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.

Nat Commun 11, 4748 (2020)
Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial.

Cancer 126, 4859-4866 (2020)
Sex differences in oncogenic mutational processes.

Nat Commun 11, 4330 (2020)
Patterns of somatic structural variation in human cancer genomes.

Nature 578, 112-121 (2020)
Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors.

Commun Biol 3, 310 (2020)
Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

Imaging mass cytometry and multiplatform genomics define the phenogenomic landscape of breast cancer

Nature Cancer 1, 163-175 (2020)
Eleven grand challenges in single-cell data science.

Genome Biol 21, 31 (2020)
The repertoire of mutational signatures in human cancer.

Nature 578, 94-101 (2020)
Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

Nature 578, 102-111 (2020)
The evolutionary history of 2,658 cancers.

Nature 578, 122-128 (2020)
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.

Nature genetics 52, 331-341 (2020)
The landscape of viral associations in human cancers.

Nature genetics 52, 320-330 (2020)
Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.

Nature genetics 52, 294-305 (2020)
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

Nature genetics 52, 306-319 (2020)
Comprehensive molecular characterization of mitochondrial genomes in human cancers.

Nature genetics 52, 342-352 (2020)
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.

Communications biology 3, 56 (2020)
Pathway and network analysis of more than 2500 whole cancer genomes.

Nature communications 11, 729 (2020)
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.

Nature communications 11, 728 (2020)
Integrative pathway enrichment analysis of multivariate omics data.

Nature communications 11, 735 (2020)
Inferring structural variant cancer cell fraction.

Nature communications 11, 730 (2020)
Reconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.

Nature communications 11, 731 (2020)
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.

Nature communications 11, 736 (2020)
Divergent mutational processes distinguish hypoxic and normoxic tumours.

Nature communications 11, 737 (2020)
Combined burden and functional impact tests for cancer driver discovery using DriverPower.

Nature communications 11, 734 (2020)
Genomic footprints of activated telomere maintenance mechanisms in cancer.

Nature communications 11, 733 (2020)
Pan-cancer analysis of whole genomes.

Nature 578, 82-93 (2020)
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays.

Biochem Biophys Res Commun 523, 795-801 (2020)
2019
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

Cell 179, 1207-1221.e22 (2019)
Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses.

Genome Biol 20, 210 (2019)
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

Nat Methods 16, 1007-1015 (2019)
Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.

Commun Biol 2, 165 (2019)
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

Nature 567, 399-404 (2019)
clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers.

Genome Biol 20, 54 (2019)
2018
Decoding Transcriptome Dynamics of Genome-Encoded Polyadenylation and Autoregulation with Small-Molecule Modulators of Alternative Polyadenylation.

Cell Chem Biol 25, 1470-1484.e5 (2018)
High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations.

Stem Cell Reports 11, 578-592 (2018)
Discovery of 3-Benzyl-1-( trans-4-((5-cyanopyridin-2-yl)amino)cyclohexyl)-1-arylurea Derivatives as Novel and Selective Cyclin-Dependent Kinase 12 (CDK12) Inhibitors.

J Med Chem 61, 7710-7728 (2018)
Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Cell 173, 1755-1769.e22 (2018)
Homologous recombination deficiency and host anti-tumor immunity in triple-negative breast cancer.

Breast cancer research and treatment 171, 21-31 (2018)
Associations between genomic stratification of breast cancer and centrally reviewed tumour pathology in the METABRIC cohort.

NPJ breast cancer 4, 5 (2018)
2017
Homologous Recombination Deficiency in Breast Cancer: A Clinical Review.

JCO precision oncology 1, 1-13 (2017)
Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.

Sci Rep 7, 13467 (2017)
Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab).

Breast Cancer Res Treat 164, 571-580 (2017)
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay.

ACS Chem Biol 12, 1760-1768 (2017)
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

Nat Genet 49, 856-865 (2017)
Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors.

J Med Chem 60, 3335-3351 (2017)
CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Nucleic Acids Res 45, 6698-6716 (2017)
Atrophin controls developmental signaling pathways via interactions with Trithorax-like.

Elife 6, (2017)
Discovery of selective ATP-competitive eIF4A3 inhibitors.

Bioorg Med Chem 25, 2200-2209 (2017)
ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data.

Genome Biol 18, 44 (2017)
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

Nat Commun 8, 7 (2017)
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Nat Commun 8, 14432 (2017)
Scalable whole-genome single-cell library preparation without preamplification.

Nat Methods 14, 167-173 (2017)
The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation.

Biochem Biophys Res Commun 483, 271-276 (2017)
2016
Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

Cancer Metastasis Rev 35, 547-573 (2016)
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery.

Cell 167, 1145-1149 (2016)
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.

Cell Rep 17, 2060-2074 (2016)
A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds.

Cell 167, 260-274.e22 (2016)
Direct Transcriptional Consequences of Somatic Mutation in Breast Cancer.

Cell Rep 16, 2032-46 (2016)
Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Proc Natl Acad Sci U S A 113, 8484-9 (2016)
Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers.

Sci Signal 9, ra69 (2016)
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer.

Breast Cancer Res 18, 70 (2016)
Corrigendum: Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Genome Res 26, 717.2 (2016)
Clonal genotype and population structure inference from single-cell tumor sequencing.

Nat Methods 13, 573-6 (2016)
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

Nat Genet 48, 758-67 (2016)
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

Nat Commun 7, 11479 (2016)
Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro.

PLoS One 11, e0150675 (2016)
2015
Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers.

Cold Spring Harb Mol Case Stud 1, a000570 (2015)
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells.

Nature 528, 267-71 (2015)
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.

Nat Commun 6, 8554 (2015)
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.

Genome Res 25, 814-24 (2015)
Examining the utility of patient-derived xenograft mouse models.

Nat Rev Cancer 15, 311-6 (2015)
Lapatinib or Trastuzumab Plus Taxane Therapy for Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: Final Results of NCIC CTG MA.31.

J Clin Oncol 33, 1574-83 (2015)
A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

Breast Cancer Res 17, 4 (2015)
In vivo radioimaging of bradykinin receptor b1, a widely overexpressed molecule in human cancer.

Cancer Res 75, 387-93 (2015)
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Nature 518, 422-6 (2015)
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Mol Oncol 9, 115-27 (2015)
2014
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts.

Nat Commun 5, 5871 (2014)
Tumor heterogeneity: next-generation sequencing enhances the view from the pathologist's microscope.

Genome Biol 15, 463 (2014)
Genome-driven integrated classification of breast cancer validated in over 7,500 samples.

Genome Biol 15, 431 (2014)
Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

Science 345, 1251343 (2014)
TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Genome Res 24, 1881-93 (2014)
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

J Pathol 234, 386-97 (2014)
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.

Proc Natl Acad Sci U S A 111, 11133-8 (2014)
Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

Haematologica 99, 1456-64 (2014)
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

Clin Cancer Res 20, 3569-80 (2014)
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Blood 123, 3914-24 (2014)
The Breast Cancer Oncogene EMSY Represses Transcription of Antimetastatic microRNA miR-31.

Mol Cell 54, 203 (2014)
Processed pseudogenes acquired somatically during cancer development.

Nat Commun 5, 3644 (2014)
PyClone: statistical inference of clonal population structure in cancer.

Nat Methods 11, 396-8 (2014)
The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31.

Mol Cell 53, 806-18 (2014)
Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells.

Cell Stem Cell 14, 253-63 (2014)
The omics of triple-negative breast cancers.

Clin Chem 60, 122-33 (2014)
2013
Solution NMR structure and histone binding of the PHD domain of human MLL5.

PLoS One 8, e77020 (2013)
Signatures of mutational processes in human cancer.

Nature 500, 415-21 (2013)
TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells.

Mol Cancer Res 11, 1179-92 (2013)
Improving breast cancer survival analysis through competition-based multidimensional modeling.

PLoS Comput Biol 9, e1003047 (2013)
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer.

Sci Transl Med 5, 181re1 (2013)
The implications of clonal genome evolution for cancer medicine.

N Engl J Med 368, 842-51 (2013)
A new genome-driven integrated classification of breast cancer and its implications.

EMBO J 32, 617-28 (2013)
2012
DriverNet: uncovering the impact of somatic driver mutations on transcriptional networks in cancer.

Genome Biol 13, R124 (2012)
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through MAPK activation.

PLoS One 7, e39653 (2012)
The landscape of cancer genes and mutational processes in breast cancer.

Nature 486, 400-4 (2012)
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

Genome Res 22, 1995-2007 (2012)
Quiz page June 2012: kidney failure in an HIV-positive patient.

Am J Kidney Dis 59, A27-30 (2012)
Mutational processes molding the genomes of 21 breast cancers.

Cell 149, 979-93 (2012)
The life history of 21 breast cancers.

Cell 149, 994-1007 (2012)
The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

Nature 486, 346-52 (2012)
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Nature 486, 395-9 (2012)
Opening Pandora's Box--the new biology of driver mutations and clonal evolution in cancer as revealed by next generation sequencing.

Curr Opin Genet Dev 22, 3-9 (2012)
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data.

Bioinformatics 28, 907-13 (2012)
Molecular alterations between the primary breast cancer and the subsequent locoregional/metastatic tumor.

Oncologist 17, 172-8 (2012)
Recurrent somatic DICER1 mutations in nonepithelial ovarian cancers.

N Engl J Med 366, 234-42 (2012)
Feature-based classifiers for somatic mutation detection in tumour-normal paired sequencing data.

Bioinformatics 28, 167-75 (2012)
Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques.

Exp Mol Pathol 92, 33-43 (2012)
2011
PPM1H is a p27 phosphatase implicated in trastuzumab resistance.

Cancer Discov 1, 326-37 (2011)
Mll5 is required for normal spermatogenesis.

PLoS One 6, e27127 (2011)
Raman microscopy-based cytochemical investigations of potential niche-forming inhomogeneities present in human embryonic stem cell colonies.

Appl Spectrosc 65, 1009-16 (2011)
High-throughput microfluidic single-cell RT-qPCR.

Proc Natl Acad Sci U S A 108, 13999-4004 (2011)
Absolute quantification of intracellular glycogen content in human embryonic stem cells with Raman microspectroscopy.

Anal Chem 83, 6254-8 (2011)
Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.

Exp Hematol 39, 866-79.e1 (2011)
Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells.

Blood 118, 3350-8 (2011)
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.

BMC Genomics 12, 209 (2011)
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

EMBO Mol Med 3, 167-80 (2011)
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Blood 117, 2451-9 (2011)
P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer.

Mod Pathol 24, 64-81 (2011)
2010
The orphan adhesion-GPCR GPR126 is required for embryonic development in the mouse.

PLoS One 5, e14047 (2010)
Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.

Cancer Res 70, 8770-81 (2010)
ARID1A mutations in endometriosis-associated ovarian carcinomas.

N Engl J Med 363, 1532-43 (2010)
Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.

Breast Cancer Res 12, R38 (2010)
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Nat Genet 42, 181-5 (2010)
Does massively parallel DNA resequencing signify the end of histopathology as we know it?

J Pathol 220, 307-15 (2010)
2009
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy.

Breast Cancer Res 11, R87 (2009)
Evolutionary concepts in biobanking - the BC BioLibrary.

J Transl Med 7, 95 (2009)
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.

Nature 461, 809-13 (2009)
p53: a new kingpin in the stem cell arena.

Cell 138, 1060-2 (2009)
Mutation of FOXL2 in granulosa-cell tumors of the ovary.

N Engl J Med 360, 2719-29 (2009)
Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis.

BMC Cancer 9, 165 (2009)
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

Blood 113, 1432-43 (2009)
Columnar cell lesions, mammographic density and breast cancer risk.

Breast Cancer Res Treat 115, 561-71 (2009)
2008
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability.

Nat Med 14, 1384-9 (2008)
A loss of function allele for murine Staufen1 leads to impairment of dendritic Staufen1-RNP delivery and dendritic spine morphogenesis.

Proc Natl Acad Sci U S A 105, 16374-9 (2008)
Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells.

Cytometry A 73, 904-17 (2008)
Transcriptome analysis of the normal human mammary cell commitment and differentiation process.

Cell Stem Cell 3, 109-18 (2008)
Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer?

Virchows Arch 452, 589-98 (2008)
2007
Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.

BMC Med 5, 33 (2007)
Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy.

Breast Cancer Res 9, R61 (2007)
Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene.

Proc Natl Acad Sci U S A 104, 10714-9 (2007)
2006
Systematic genome-wide annotation of spliceosomal proteins reveals differential gene family expansion.

Genome Res 16, 66-77 (2006)
2005
Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.

Cell Metab 1, 293-6 (2005)
PEDF and the serpins: phylogeny, sequence conservation, and functional domains.

J Struct Biol 151, 130-50 (2005)
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

Proc Natl Acad Sci U S A 102, 1761-6 (2005)
2004
Genetic approaches to unraveling G protein-coupled receptor biology.

Curr Opin Drug Discov Devel 7, 658-64 (2004)
p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels.

Proc Natl Acad Sci U S A 101, 7386-91 (2004)
Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes.

Mol Biol Evol 21, 1146-51 (2004)
Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling.

BMC Genomics 5, 9 (2004)
2003
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.

Cell 115, 523-35 (2003)
The GPR54 gene as a regulator of puberty.

N Engl J Med 349, 1614-27 (2003)
2002
Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes.

Science 297, 1301-10 (2002)
The molecular outlook.

Nature 415, 484-5 (2002)