Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.

Samuel A J R Aparicio, Cell metabolism 1, 293-6 (2005)


Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.