p53: a new kingpin in the stem cell arena.

Samuel Aparicio, Connie J Eaves, Cell 138, 1060-2 (2009)


Identifying new regulators of the stem cell state offers potential for future gains in biomedicine. Evidence that the tumor suppressor p53 is a key regulator of the stem cell state (Cicalese et al., 2009) suggests a broad role for this protein and its pathways in the control of normal tissue homeostasis and tumor formation.