Job Summary

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and to gain a better understanding of tumor microenvironment. Researchers uses the latest Single Cell Genomics technologies to rapidly identify genes that are involved in the development of cancer. This position will be working on the Single Cell Genomic research projects currently on-going in the research lab, providing technical guidance, expertise, and support to other internal/external researchers on Single Cell Genomics, in addition, helping with continual development and on-going production at 2 separate research facilities located in Vancouver, B.C.

We are seeking a highly-motivated and highly skilled individual with expertise or experience in single cell genomics, robotics, next-generation sequencing and a strong background in molecular biology. The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. Individual should possess a strong molecular biology background; experience with liquid handling robotics is considered an asset. Experience with bioinformatics approaches to biological data and familiarity with handling of genomics and next-generation sequencing data will be an advantage. This position will provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

Organizational Status

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory Research and Operations Manager, in addition, the applicant may assist in overseeing technical work of students and trainees. More information on the lab, please visit https://aparicio.molonc.ca

Consequence of Error/Judgement

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

Supervision Received

The successful applicant will work under minimum supervision. From time to time, Principal Investigator or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.

Supervision Given

Depending on experience and expertise, the successful applicant maybe be required to assist in training and supervision of graduate students/trainees, junior staff, or external collaborators; including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

Minimum Qualifications

Completion of a university degree in a relevant discipline or technical program and a minimum four years of related experience or an equivalent combination of education and experience. Some positions may require a graduate degree.

A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 4-5 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in single cell genomics biology or molecular biology.

Preferred Qualifications

• Plans and performs experiments utilizing established complex procedures and/or techniques for investigating single cell genomics, involving the use of liquid handling robotics and 10x genomics platforms
• Visualize and analyze cells using microscopy and flowcytometry.
• Generation, preparation and submission of next-generation sequencing libraries.
• Using a LMIS system to track and record sample data
• Provide technical expertise and support in molecular biology, protein biochemistry, tissue culture and virology
• Develop and implement standard operating protocols (SOPs).
• Maintains laboratory records and experimental data.
• Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
• Conducts complex data analysis and interpretation of data resulting from high throughput experiments.
• Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications.
• Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.
• A working knowledge and understanding of molecular biology and biochemistry techniques such as next-generation sequencing, PCR, DNA/RNA purification and cloning techniques is essential; prior working experience in next-generation sequencing and library construction is considered a great asset.
• Experience with cell culture and aseptic technique.
• Working hands-on experience in tissue handling and tissue dissociation methods would be an asset.
• Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
• Preference will be given to applicants with liquid handling robotics, single cell genomics, next-generation sequencing, and 10x Genomics experience.
• Experience in immunocytochemistry and basic data analysis in R or similar statistics package would be an asset.
• Demonstrated understanding of experimental design and assay optimization.
• Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
• Excellent documentation and organizational skills.
• Able to multi-task, prioritize and handle multi-project assignments concurrently.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Please include the following documents when applying:

• Cover Letter
• CV
• Contact information for two or three references

Apply online now

POSITION DESCRIPTION

The post holder will support and work closely with Dr Aparicio, leader of Molecular Oncology, UBC Nan and Lorraine Robertson Chair of Breast Cancer, in developing scientific proposals, assisting in manuscript development and review, coordinating international multi-PI research studies and interacting with funders and advocates in reporting the activities of the program. A PhD with demonstrated experience in authoring manuscripts, preparing funding applications and reports, is a requirement for the role. Preference will be given to candidates with experience in biosciences and cancer research. Ability to articulate science clearly in a written form and a high degree of independence and self organization are core skills for this post.

WORK PERFORMED

• Provide input into writing research proposals and writes significant portions of grant applications.
• Develops and recommends project budgets, monitors expenditure of funds relative to budget, ensures appropriate, transparent justifications for expenditures. Participates in the development and implementation of new projects, by developing new material, researching and sourcing equipment and recommending staffing and resource * requirements.
• Manages and develops necessary agreements for the Aparicio program in conjunction with the BC Cancer Technology Development Office and UBC Office of Research Services/University-Industry Liaison Office.
• Responds to ongoing requests for regular reports by maintaining and updating information to ensure compliance with granting agencies and other external organizations.
• Serves as a primary point of liaison between researchers, administrators, and funding agencies REBs, national and international health organizations, educational institutions, government and private agencies.
• Identifies opportunities for developing new initiatives, grants and projects that enhance funding of research in the Aparicio program. This may include, but is not limited to funding from external organizations such as MSFHR, CIHR, Genome Canada, CFI, NSERC, NCIC, LRF, NIH, the provincial government and industry.
• Assists with Research Ethics Board applications and amendments as required, and ensures compliance with Research Ethics Board guidelines.
• Develops and maintains a clear engagement and communication plan for both internal and external audiences. This includes promotion and representation of Aparicio program research through websites and social media platforms, and the development and facilitation of workshops, conferences, guest lecturers, etc.
• Identifies new translational pathways, such as commercial partnerships, licencing etc. for new technologies and encourage entrepreneurial activities as appropriate.
• Conducts regular literature reviews relating to research areas. Contributes intellectual and scientific input to manuscripts for publications, provides scientific proofreading.

QUALIFICATIONS

Interested individuals with a PhD or MD/PhD, a strong publication record and excellent academic credentials are encouraged to apply. Experience in grant preparation and scientific manuscript preparation is required.

• Strong interpersonal skills and the ability to work effectively with internal and external stakeholders who possess a wide range of education and expertise.
• Ability to use independent judgment and to manage and impart information to a diverse range of internal and external stakeholders.
• Ability to exercise appropriate tact, discretion, confidentiality, and good judgment in all matters.
• Knowledge of and/or experience in project management principles, accounting and fiscal management is preferable.

More information on the lab, please visit https://aparicio.molonc.ca

This is a one year appointment and depending on funding and successful progress of the research it may be renewed for additional years.

UBC hires on the basis of merit and is committed to employment equity. All qualified persons are encouraged to apply. UBC is strongly committed to diversity within its community and especially welcomes applications from visible minority group members, women, Aboriginal persons, persons with disabilities, persons of any sexual orientation or gender identity, and others who may contribute to the further diversification of ideas. However, Canadians and permanent residents of Canada will be given priority.

We thank all interested applicants for their interest, however, only those applicants short-listed will be contacted for an interview.

Apply online now

JOB SUMMARY

The Aparicio lab uses the latest technologies to rapidly identify genes that are involved in the development of breast cancer. Through the use of single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues, we hope to gain a better understanding of tumor microenvironment. In addition, we explore the effect drugs on tumor evolution through the use of patient derived xenograft and CRISPR-Cas9. This position involves providing high level, senior technical support in the main areas of molecular biology, biochemistry and cell biology for researchers on current on-going research projects.

We are seeking a highly-motivated and highly skilled individual with expertise or experience in cloning, sub-cloning, CRISPR-Cas9, next-generation sequencing and a strong background in molecular biology; with recent hands-on experience in DNA/RNA extraction and handling, subcloning, cloning and tissue culture. Furthermore, experience, understanding and familiarity with handling of genomics DNA for next-generation sequencing and preparation of next-generation sequencing library will be an advantage.

The successful applicant will work full-time under the direction and supervision of both Dr. Samuel Aparicio, Principal Investigator, and the Laboratory Research and Operations manager. The position will provide the candidate with a high level of exposure to all current on-going project within Aparicio Lab, such as areas of single cell genomics and translational research, CRISPR-cas9 and patient derived xenograft drug screening, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally; position start date is flexible.

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, or Laboratory and Research Operation Manager, in addition, the applicant may assist in overseeing technical work of students and trainees. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

• Plans and performs advance procedures, complex experiments and/or techniques of molecular biology, biochemistry and cell biology for current on-going research projects
• Oversee progression of projects assigned, in addition, participate, and provide suggestion or expertise for other research activities on-going.
• Generation, preparation and submission of next-generation sequencing libraries.
• Using a LIMS system to track and record sample data
• Provide senior level technical expertise and support in molecular biology, protein biochemistry, tissue culture and virology
• Developing and implementing standard operating protocols (SOPs).
• Maintains laboratory records and experimental data.
• Assist in general lab maintenance such as reagent preparation, receiving and inventory of lab supplies.
• Assist, develop and/or update Standard Operating Procedures (SOPs) to ensure compliance with regulatory bodies.
• Presents data at scientific meetings, writes reports and contributes to writing ethics and grant applications when required.
• Assist in general maintenance of the lab and receiving and inventory of lab supplies.
• Provide training and instruction for specialized techniques and equipment.
• Provide expertise in the area of Molecular Biology, Biochemistry and Cell Biology to help troubleshoot complex experimental methods and procedure for staff, junior staff, trainees and students.
• Assist lab manager with oversight of trainee students.
• Optimizing existing protocols, as well as, developing new protocol to improve throughput, quality control, efficiency, and/or robustness in collaboration with teammates and other research staff.
• Carries out any other related duties as assigned or required in keeping with the qualifications and requirements of this technician level.

CONSEQUENCE OF ERROR

The work is of a complex nature and required high level of training, tasks are assigned and the incumbent exercises a considerable amount of responsibility, initiative and judgment in determining own work schedule to achieve those tasks. Errors may result in the permanent loss of irreplaceable tissue samples, loss of thousands of dollars of material and/or damage to equipment. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly. Noncompliance with biosafety and chemical safety regulations may also result in closure of facility or loss of grant funding.

SUPERVISION RECEIVED

The successful applicant will work under minimum supervision. From time to time, Principal Investigator or Laboratory Research and Operations Manager may provide specific instructions on unusual problems, or new project outlines. This position will report to the Principal Investigator or Laboratory Research and Operations Manager.

SUPERVISION GIVEN

Depending on experience and expertise, the successful applicant is expected to assist in training and supervision of graduate students/trainees or junior staff, including providing instruction on use of lab equipment and procedures, and will help troubleshoot experiments in their area of expertise.

QUALIFICATIONS

• A MSc in Biological Sciences (Molecular Biology or other relevant field) or BSc with 3-5 years of related experience in academic research or biotech industry settings, preference will be given to applicants with work experience in single cell genomics biology or molecular biology.
• A working knowledge and understanding of advance molecular biology and biochemistry techniques such as next-generation sequencing, PCR, DNA/RNA purification and cloning techniques is essential; prior working experience in next-generation sequencing and library construction is considered a great asset.
• Experience with cell culture and aseptic technique.
• Working hands-on experience in tissue handling and tissue dissociation methods would be an asset.
• Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques including the following: RNA / DNA isolation, quantitative PCR, transfection, flow cytometry, immunohistochemistry, ELISA, protein isolation, and western blotting.
• Preference will be given to applicants with, molecular cloning and subcloning, single cell genomics, next-generation sequencing, and 10x Genomics experience.
• Demonstrated understanding of experimental design and assay optimization.
• Strong interpersonal skills, communication skills (orally and written) and the ability to interact positively and productively with other team members are essential.
• Excellent documentation and organizational skills.
• The successful candidate must be well-organized, conscientious, understand the importance of detail, and be able to multi-task and prioritize duties effectively.

Apply online now

We are seeking a highly-motivated post-doctoral fellow (PDF) with strong leadership ability and expertise in single cell genomics and transcriptomics, and a strong background in molecular biology. The successful applicant will work full-time under the supervision of Dr. Samuel Aparicio. The position start date is flexible.

JOB SUMMARY

The Aparicio lab is developing new single cell genome and transcriptome methods for tracking clonal trajectories at single cell level in patient tissues and patient-derived xenografts (PDX). A PDF position is available in the Aparicio lab based at the BC Cancer Research Center in Vancouver, Canada, collaborating on an exciting project mapping clonal dynamics in human cancers with new single cell methods. The post holder will have the opportunity to interact as part of the international CRUK Grand Challenge IMAXT project, bringing new measurement methods and computational techniques to the 3D reconstruction of tumours, and mapping drug sensitivity and drug combinations using sgRNA/CRISPR methods in vivo. The program works closely with the Shah computational biology program, based at Memorial Sloan Kettering Cancer Centre, on the development of new models for single cell data and cancer evolution. Some experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage. More information on the lab, please visit https://aparicio.molonc.ca

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Center in Vancouver, British Columbia, Canada. The candidate will report directly to Dr. Samuel Aparicio, and will play a senior leadership role in the laboratory.

WORK PERFORMED

• Provide leadership, strategic direction, and translational research pertaining to single cell genomics and transcriptomics, and CRISPR methods.
• Design and implement research plan to investigate the clonal dynamics in human cancer through single cell methods.
• Design and conduct animal experiments.
• Conduct in vivo testing or characterization of drugs, small molecules, knockouts or antibodies in relevant PDX animal models.
• Foster research collaborations and work jointly with academic, clinical, industry, and other partners.
• Scientifically document lab experiments, data analysis, interpretations.
• Write manuscripts, present results at internal and external meetings.
• Identify funding opportunities and if required write or assist with grant proposals
• Lead and mentor junior trainees/students in the laboratory

CONSEQUENCE OF ERROR

This is a senior research position that plays a critical role in the development of this novel field. PDF is accountable for the quality and integrity of the research and data, including analyses and interpretation, as well as the effective and efficient management of research projects and deliverables. This position requires innovation, strategic planning, and adaptability. Incorrect decisions or actions may damage the reputation of the laboratory, lead to loss of credibility in this field, and be financially costly.

SUPERVISION RECEIVED

The PDF will work with a high degree of independence and set priorities under broad directives from Dr. Aparicio. The PDF will be expected to provide direction and mentoring in the laboratory under the supervision of Dr. Aparicio. This position will also provide the candidate with a high level of exposure to single cell genomics and translational research, as well as, providing opportunities to work collaboratively with industry partners and other researchers globally.

SUPERVISION GIVEN

The PDF will be expected to provide mentorship and guidance to undergraduate, graduate students and other research members as required.

QUALIFICATION

• Ph.D. in biology, cell biology, molecular biology, biochemistry, genetics, genomics, or similar discipline.
• The candidate should have a solid scientific and technical background with excellent written/oral communication, interpersonal and organizational skills.
• Preference will be given to candidates with a proven track record with a minimum of 2-3 first author publications in reputable journals.
• Proficiency in cell biology, molecular biology, histology, genetics, genomics, next-generation sequencing and biochemistry techniques.
• Demonstrate the ability to work in a highly interdisciplinary environment.
• Experience with cancer research.
• Expertise and hands-on experience in animal studies, including all aspects of design, handling, breeding, tissue collection, histology, and analyses are essential.
• Familiarity with testing/characterization of small molecule or drug in vivo is preferred.
• Previous biochemical/cell biology and molecular biology experience with single cell genomics / transcriptomics, next generation sequencing, drugs screen and PDX modeling is an asset.
• Experience with statistical analyses and scientific writing. Previous experience with grant writing is an asset.
• Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data is an asset.
• Applicants with experience and a strong track record with large drug target screening, single cell methods, and PDX mouse models are especially encouraged to apply.

To apply: Please send your Cover Letter, CV, Transcript and Work Sample to careersmolonc@bccrc.ca

Please put your full name and job title “Post-doctoral Fellow (PDF) Single Cell Genomics, Molecular Biology” in the subject line.

JOB SUMMARY

The candidate would work within a dynamic and vibrant lab with a proven track record of outstanding achievements and contributions in breast oncology research. This position allows the candidate to contribute bold and innovative research that can be translated to new understanding in the evolutionary processes that drive cancers.

This position’s primary focus in the lab will be to lead and to participate in projects involving the investigation of functional genomics using sequencing and expression data for breast oncology and cancer evolution. Using the wide network of connections and collaborations of the principal investigator, and extensive biomedical resources at the institution, candidates will be able to build on the existing research of the lab to quickly start up their own research projects.

The position will provide a unique opportunity for mentoring trainees, supervising analysts and interacting with industry. This is an excellent platform to receive outstanding training to gain the important skills for a successful medical research career in academia or industry.

This funded position with the University of British Columbia, at the BC Cancer Research Centre allows the candidate to flourish under the guidance of an experienced mentor

ORGANIZATIONAL STATUS

Aparicio Lab is located in the department of Molecular Oncology at BC Cancer Research Institute in Vancouver, British Columbia, Canada. The Postdoctoral Fellow will play a leadership role in the Aparicio lab, and will be reporting directly to Dr. Samuel Aparicio who is the primary investigator of the laboratory. More information on the lab, please visit https://aparicio.molonc.ca

WORK PERFORMED

• Management and supervision of trainees;
• May be involved in recruitment and training of trainees;
• Performing regular reviews of the relevant literature;
• Planning and designing of experiments;
• Analyzing, interpreting and compiling data in study reports, presenting results, and participating in the preparation of scientific manuscripts and grant application packages;
• Updating Dr. Aparicio and the group on the status of projects during lab meetings, in email correspondence and phone conferences;
• Managing projects with key academic and industry partners.

SUPERVISION RECEIVED

• Works independently under direction of PI, Dr. Samuel Aparicio
• Opportunities to work collaboratively with Industry partners and other researchers at UBC and globally

SUPERVISION GIVEN

• Assists and oversees research assistants and students as required
• Assists and provides guidelines to other research members, as required

QUALIFICATIONS

• PhD degree in the computer science, bioinformatics or equivalent
• At least 4 years experience in bioinformatics research
• Experience in genomics and next-generation sequencing
• Extensive knowledge of cellular and molecular biology, biochemistry and genetics
• Experience with cancer research a plus
• Proven ability to multi-task in a deadline oriented environment with minimal supervision
• Effective oral and written communication, analytical, and interpersonal skills
• Excellent organizational skill and ability to learn new skills quickly
• Ability to work independently and within a team environment.
• Accuracy and attention to detail required
• Candidates should demonstrate the ability to work in a highly interdisciplinary environment.

HOW TO APPLY

Exceptional candidates should submit a cover letter outlining your research interests and fit with the laboratory’s research, curriculum vitae, and the names of three referees willing to provide letters of reference.

Due to the number of resumes we receive, we are unable to confirm receipt of submissions over the phone, or provide the status of the competition. Only shortlisted candidates will be contacted.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

To apply: Please include your Cover Letter, CV, Transcript and Work Sample to the application.

Apply online now