Steve McKinney

Staff Scientist
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Armed with a PhD in Biostatistics from the University of Washington, Steven McKinney is our resident statistician helping us maintain the quality and significance of all of our numerical work since the beginning of the lab.

Papers

Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461.

Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes.

Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro.

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer.

Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells.

TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance.

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups.

Mll5 is required for normal spermatogenesis.

Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques.

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.

ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium.

Synthetic lethality screens reveal RPS6 and MST1R as modifiers of insulin-like growth factor-1 receptor inhibitor activity in childhood sarcomas.

P-cadherin expression as a prognostic biomarker in a 3992 case tissue microarray series of breast cancer.

Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development.

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.

Intensity calibration and automated cell cycle gating for high-throughput image-based siRNA screens of mammalian cells.

Transcriptome analysis of the normal human mammary cell commitment and differentiation process.

Columnar cell lesions, mammographic density and breast cancer risk.

Kisspeptin and GPR54 immunoreactivity in a cohort of 518 patients defines favourable prognosis and clear cell subtype in ovarian carcinoma.