Single-cell genomic variation induced by mutational processes in cancer.

Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.

Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation.

Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.

Atrophin controls developmental signaling pathways via interactions with Trithorax-like.

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor.

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Clonal genotype and population structure inference from single-cell tumor sequencing.

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer.

A co-culture genome-wide RNAi screen with mammary epithelial cells reveals transmembrane signals required for growth and differentiation.

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data.

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

PyClone: statistical inference of clonal population structure in cancer.

Solution NMR structure and histone binding of the PHD domain of human MLL5.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Mll5 is required for normal spermatogenesis.

Retinoblastoma-binding proteins 4 and 9 are important for human pluripotent stem cell maintenance.

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation.

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.