Daniel Lai

Senior Bioinformatics Scientist
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Daniel has a background in microbiology, immunology and computer science, and has specialized in the analysis of next-generation genomics sequencing data. He currently manages a small team of programmers and analysts in a breast cancer research lab, helping medical researchers study genomic changes in cancer evolution and assisting in therapeutics discovery.


Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

Single-cell genomic variation induced by mutational processes in cancer.

Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.

Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies.

Clonal fitness inferred from time-series modelling of single-cell cancer genomes.

Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data.

Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors.

Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.

Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses.

Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers.

Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer.

Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.

Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes.

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.

Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates.

Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer.

The clonal and mutational evolution spectrum of primary triple-negative breast cancers.