Single-cell genomic variation induced by mutational processes in cancer.
Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.
Clonal fitness inferred from time-series modelling of single-cell cancer genomes.
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing.
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.
Mll5 is required for normal spermatogenesis.
The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent.
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation.