Ciara O'Flanagan

Research Associate
Email
coflanaganobfuscate@bccrc.ca
LinkedIn

Ciara has a PhD in cancer biology and a background in the cell biology of progressive breast cancer. Her current research involves the development of high throughput imaging and drug screening techniques to study the relationship between the genomic and transcriptomic landscape and response to treatment in breast and ovarian cancers.

Papers

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.

Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomes.

Luminal breast epithelial cells from wildtype and BRCA mutation carriers harbor copy number alterations commonly associated with breast cancer

Expansion microscopy using a single anchor molecule for high-yield multiplexed imaging of proteins and RNAs.

Reconstructing clonal tree for phylo-phenotypic characterization of cancer using single-cell transcriptomics.

Single-cell genomic variation induced by mutational processes in cancer.

Accurate determination of CRISPR-mediated gene fitness in transplantable tumours.

Clonal fitness inferred from time-series modelling of single-cell cancer genomes.

Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses.

Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling.

clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers.